Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/11900
Structural changes in sheep tibia bone undergoing biomaterial scaffold implant
Bone fracture is a common occurrence with most people having, or knowing someone who has experienced it. This thesis displays quantitative results on the growth and strength of new material formed in a fracture gap by analysing the density and volume of the implanted biomaterial scaffold and the new material formed alongside gait and Finite Element Analysis (FEA) of external factors which can have an effect on the remodeling process. The main goal of this thesis is to present methods to provide quantitative results specifically related to the formation of new material with the implant of a biomaterial scaffold.
Skeletally mature sheep were used in the trial in which 21 sheep were randomized into 3 groups of 7. Each group had a 25 mm induced fracture in the rear right leg tibia of each sheep into which three scaffold groups were placed. CT scans were taken of the tibia and quantitative results were gathered on several aspects of the scaffold, new growth material and also of external stimulation factors. External stimulation factors measured were the gait of the sheep, the screw forces experienced and stress shielding due to the fracture plate.
All groups displayed new material growth to some extent with some specimens displaying healing patterns similar to those expected in secondary healing. It was shown that the sheep were using the injured legs but not to the extent of first thought which coupled with the stress shielding found in the plate can be expected to affect the remodeling process.