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Titill

Gene expression in mammalian innate immunity: 4-PBA and ST7 reduce CRAMP gene expression in murine lung epithelial cells

Útdráttur

Antimicrobial peptides are an important component of the human and mammalian innate immunity. These peptides greatly contribute to the protective barrier against microbes found on all epithelial surfaces and therefore enable us and all other multicellular organisms to live harmoniously with those intruding microbes. Antimicrobial peptides consist of two families, the defensins and the cathelicidins. Only one cathelicidin has been identified in humans, CAMP/hCAP18/LL-37. CAMP gene expression has been shown to be induced by a variety of different agents, such as vitamin D3, butyrate and phenylbutyrate. These findings are of great interest due to the increasing number of drug-resistant bacteria in recent years. There are hopes that in the near future induced CAMP expression, mediated by topically applied agents, would become a good alternative to common antimicrobial used today.
Here we investigate the effects of 4-PBA and α-PBA treatment on the CRAMP expression in murine lung epithelial cells. We show that several heat shock proteins are involved in VDR mediated transcription. The treatment with PBAs causes a significant reduction of the cellular CRAMP concentration because the expression levels of several VDR-associated heat shock proteins are affected as well.

Birting
19.2.2009


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