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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: https://hdl.handle.net/1946/19146

Titill: 
  • Titill er á ensku The effect of the renin-angiotensin system on contractillity of retinal arterioles
Námsstig: 
  • Meistara
Útdráttur: 
  • In this in vivo study the contractility of small vessels in bovine retina was examined using Myograph technology. The purpose was to investigate the effects of the local renin-angiotensin pathway on the contractility in those retinal arterioles.
    RAS has an essential role throughout the body in controlling blood pressure, body fluid balance and electrolyte homoeostasis. Evidence suggests that a local tissue RAS system is present in the eyes. All components of the RAS are believed to be expressed in the retina and the eye contains an Ang II formation system. The RAS is known to play important role in the development of diabetic retinopathy, retinopathy of prematurity, age related macular degeneration and glaucoma. ACE inhibitors block the conversion of Ang I to Ang II, leading to decreased activation of both AT1R and AT2R. ACE inhibitors, inhibit vasoconstriction and other mechanisms that raise blood pressure as well as vascular hypertrophy, endothelial dysfunction, atherosclerosis, inflammation and apoptosis is reduced.
    The vessel segment investigated was removed from the retina and an arteriole was threaded in a Myograph 410a. The contraction of the arteriole was recorded before and after adding the chemicals that was tested each time to the Myograph chamber.
    Local RAS system is percent in bovine retinal arterioles. Epinephrine, Ang II and Ang I all caused constriction in those arterioles. DIZE significantly inhibited the contraction induced by Ang II but did not significantly inhibit the contraction induced by Ang I. Captopril significantly inhibited the contraction of Ang I.

Styrktaraðili: 
  • Háskólasjóður KEA
Athugasemdir: 
  • Læst til 10.6.2019
Samþykkt: 
  • 24.6.2014
URI: 
  • http://hdl.handle.net/1946/19146


Skrár
Skráarnafn Stærð AðgangurLýsingSkráartegund 
Table of contents MSc PDF.pdf85.85 kBOpinnEfnisyfirlitPDFSkoða/Opna
References MSc PDF.pdf167.79 kBOpinnHeimildaskráPDFSkoða/Opna
Kristín Heba Gísladóttir Msc ritgerð pdf.pdf1.2 MBOpinnHeildartextiPDFSkoða/Opna