University of Iceland
Please use this identifier to cite or link to this item:
- Rat c-raf is located on chromosome 4 and may be activated by sequences from chromosome 13
Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat x mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.
- Somatic Cell and Molecular Genetics, 1988 (14), 401-405