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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20597

Titill: 
  • Titill er á ensku The v-erbA oncoprotein of the AEV transforming retrovirus binds to the promoter region of the erythroid specific band 3 gene
Útgáfa: 
  • 1994
Útdráttur: 
  • Útdráttur er á ensku

    Avian erythroblastosis virus (AEV) which carries two oncogenes, v-erbA and v-erbB causes erythroleukemia and sarcomas in young chickens and transforms embryo fibroblasts and bone marrow cells in culture. The v-erbA oncogene encodes an aberrant version of a gene for a nuclear thyroid hormone receptor (c-erbA, TR) and functions in neoplasia by blocking erythroid differentiation and by altering the growth properties of fibroblasts. Owing to the multiple point mutations and a small C-terminal deletion, v-erbA has lost the ability to bind T3, but still binds to DNA in a sequence-specific fashion. The phenotypic effects of v-erbA are correlated with and probably caused by v-erbA-mediated repression of a set of erythrocyte-specific genes, but their expression seems to be required during normal erythrocyte maturation. In differentiating erythroblasts the v-erbA oncoprotein specifically arrests expression of the avian erythrocyte anion transporter (band 3), CAII and ALA-S genes at the transcriptional level. Overexpression of the TK is required to modulate erythrocyte-specific gene expression in the presence of T3. The v-erbA oncogene might act as a constitutively active repressor of erythrocyte gene transcription, having lost its ability to depress (or activate) these genes in response to T3 or even retinoic acid.

Birtist í: 
  • Annals of the New York Academy of Sciences 1994, 724, 426-429
ISSN: 
  • 0077-8923
ISBN: 
  • 0-89766-844-8
Tengd vefslóð: 
  • http://www.ncbi.nlm.nih.gov/pubmed/7913305
  • http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=R13GxPQoZgKlew9wPvv&page=1&doc=1
  • http://www.scopus.com/record/display.url?eid=2-s2.0-0028357552&origin=resultslist&sort=plf-f&src=s&st1=ingvarsson+s&nlo=&nlr=&nls=&sid=4BACBEFC74E75BCAC7D717DA53898367.I0QkgbIjGqqLQ4Nw7dqZ4A%3a30&sot=b&sdt=b&sl=23&s=FIRSTAUTH%28ingvarsson+s%29&relpos=26&relpos=26&citeCnt=0&searchTerm=FIRSTAUTH%28ingvarsson+s%29
  • https://www.researchgate.net/publication/15286538_The_v-erbA_oncoprotein_of_the_AEV_transforming_retrovirus_binds_to_the_promoter_region_of_the_erythroid-specific_band_3_gene
Samþykkt: 
  • 18.2.2015
URI: 
  • http://hdl.handle.net/1946/20597


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