c-myc activation in spontaneous rat immunocytomas containing a 6;7 chromosomal translocation

Abstract

In summary, our studies of the rat immunocytoma show that in three different tumors (BL, MPC, RIC) in three different species (human, mouse, rat), nearly identical genetic loci (c-myc, Ig) are juxtaposed via chromosomal translocation. These three tumors represent at least two different stages of B cell maturation, and the natural histories and modes of induction of the tumors are very different. The finding that c-myc/Ig juxtaposition occurs in these three tumors suggests that this configuration plays a central role in the genesis of these B cell tumors.