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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20667

Titill: 
  • Titill er á ensku Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma
Útgáfa: 
  • Mars 1988
Útdráttur: 
  • Útdráttur er á ensku

    Renal cell carcinoma (RCC) and normal kidney tissues have been examined from 34 patients with sporadic, nonhereditary RCC. Eighteen of the 21 cytogenetically examined tumors (86%) had a detectable anomaly of chromosome arm 3p distal to band 3p11.2-p13, manifested as a deletion, combined with the nonreciprocal translocation of a segment from another chromosome or monosomy 3. Restriction-fragment-length polymorphism analysis showed loss of D1S1 heterozygosity in 16 of the 21 cases (76%). D3S2 heterozygosity was lost in 2 of 11 cases (18%). The variability of the breakpoint between 3p11.2 and 3p13 and the absence of a consistently translocated segment from another chromosome suggests a genetic-loss mechanism, while the activation of a dominant oncogene appears less likely. Together with the previously demonstrated involvement of the 3p14.2 region in a familial case, these findings suggest that RCCs may arise by the deletion of a "recessive cancer gene," as do retinoblastoma and Wilms tumor. The relevant locus must be located on the telomeric side of the D1S1 locus on the short arm of chromosome 3.

Styrktaraðili: 
  • Styrktaraðili er á ensku National Cancer Institute Grant 3ROlCA14054,the
    Swedish Cancer Society, Deutsche Forschungsgemeinschaft(DFG Ko 841/3-1). G.K. was recipient of a short-term European Molecular Biology Organization Fellowship; R.E., F.B., S.I., and J.S.
    were recipients of fellowships from the Cancer Research Institute and the Concern Foundation.
Birtist í: 
  • Proceedings of the National Academy of Sciences of the United States of America, 1988 (85), 1571-1575
ISSN: 
  • 0027-8424
Samþykkt: 
  • 6.3.2015
URI: 
  • http://hdl.handle.net/1946/20667


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