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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: https://hdl.handle.net/1946/20668

Titill: 
  • Titill er á ensku Drosophila homolog of the murine Int-1 protooncogene
Útgáfa: 
  • Maí 1988
Útdráttur: 
  • Útdráttur er á ensku

    We have isolated phage clones from Drosophila melanogaster genomic and cDNA libraries containing a sequence homologous to the murine Int-1 protooncogene. The Drosophila gene is represented by a single locus at position 28A1-2 on chromosome 2. The gene is expressed as a 2.9-kilobase-long polyadenylylated mRNA in embryo, larval, and pupal stages. It is hardly detectable in adult flies. The longest open reading frame of the cDNA clone corresponds to a protein 469 amino acids long. Alignment of the predicted amino acid sequences shows that the Drosophila protein is 86 amino acids longer than its murine counterpart. In spite of the difference in length, the two proteins are highly conserved with an overall sequence homology of 54%. Both Drosophila and murine Int-1 proteins begin with a hydrophobic leader sequence and contain cysteine residues and sites for glycosylation (four in the murine protein and one in the Drosophila protein) in conserved positions, suggesting that they play important functional roles.

Styrktaraðili: 
  • Styrktaraðili er á ensku Grant 5R01 CA 14054 awarded by the National Cancer Institute, the Swedish Cancer Society in Sweden and Grant OKKFT/TT 1986/294 from the National Foundation of Technical Development in Hungary. E.U. was on leave from the Department of Hygiene and Epidemiology, Medical School of Debrecen, Hungary, and was the recipient of a fellowship from Cancer Research Institute/Concern Foundation. M.H. had a fellowship from the Hungarian-EgyptianCultural Exchange program. J.S. and S.I. were recipients of fellowships from the Cancer Research Institute/Concern Foundation
Birtist í: 
  • Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 (9), 3034-3038
ISSN: 
  • 0027-8424
Samþykkt: 
  • 6.3.2015
URI: 
  • http://hdl.handle.net/1946/20668


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