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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20674

Titill: 
  • Titill er á ensku Differences in c-myc and pvt-1 amplification in sewa sarcoma sublines selected for adherent or non-adherent growth
Útgáfa: 
  • Mars 1990
Útdráttur: 
  • Útdráttur er á ensku

    Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-converted murine sarcoma (SEWA-AS12), we were able to separate cells adapted to the ascites form of growth from cells that can only grow in the solid form on the basis of their differential adherence to palstic. Both c-myc and pvt-1 were amplified approximately 63- to 77-fold in the non-adherent subline (SEWA-AS12-NA), but only 5- to 8-fold in the adherent subline (SEWA-AS12-ADH). This suggests that c-myc and/or pvt-1 amplification may provide a selective advantage to cells that can grow in the dissociated form.

Birtist í: 
  • International Journal of Cancer, 1990, 45, 514-520
ISSN: 
  • 0020-7136
Tengd vefslóð: 
  • http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910450324/pdf
  • http://www.ncbi.nlm.nih.gov/pubmed/2307540
  • http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=3&SID=T28PZboh9T9IwZuQQun&page=1&doc=3
  • https://www.researchgate.net/publication/20847626_Differences_in_c-myc_and_pvt-1_amplification_in_SEWA_sarcoma_sublines_selected_for_adherent_or_non-adherent_growth
Samþykkt: 
  • 10.3.2015
URI: 
  • http://hdl.handle.net/1946/20674


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