is Íslenska en English

Grein

Háskóli Íslands > Heilbrigðisvísindasvið > Rit starfsmanna >

Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20745

Titill: 
  • Titill er á ensku High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients
Efnisorð: 
Útgáfa: 
  • Ágúst 1996
Útdráttur: 
  • Útdráttur er á ensku

    Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cancer; (c) prostate cancer (patients younger than 65 years); and (d) other cancer types, The proportions of individuals carrying the mutation were 0.4% in the control population and in the patient groups 8.5%, 7.9%, 2.7%, and 1.0%, respectively, Our results indicate that BRCA2 confers a very high risk of breast cancer and is responsible for a substantial fraction of breast and ovarian cancer in Iceland, but only a small proportion of other cancers.

Styrktaraðili: 
  • Styrktaraðili er á ensku This work was supported by the Nordic Cancer Union, Science Fund of Iceland and the Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason.
Birtist í: 
  • Cancer Research, 1996, (56), 3663-3665
ISSN: 
  • 0008-5472
Samþykkt: 
  • 9.4.2015
URI: 
  • http://hdl.handle.net/1946/20745


Skrár
Skráarnafn Stærð AðgangurLýsingSkráartegund 
Johannesdottir1996CAN.pdf554.37 kBOpinnHeildartextiPDFSkoða/Opna