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Please use this identifier to cite or link to this item: http://hdl.handle.net/1946/20758

Title: 
  • Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma
Published: 
  • October 1996
Abstract: 
  • We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60% and D3S1217 (3p14.2-14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages.

Sponsor: 
  • This work was financially supported by the Swedish Cancer Society, Swedish Agency for Research Cooperation With Developing Countries (SAREC), Royal Swedish Academy of Sciences, King Gustaf V:S Jubelee fund, Cancer Foundation in Stockholm, Medical Research Council and Swedish Medical Association, Robert Lundbergs Minnesfond, and Karolinska Institute. L.-F.H. and F.C. were recipients of a fellowship from Karolinska Institute and CRI/Concern, the National Science Foundation.
Citation: 
  • Genes Chromosomes and Cancer, 1996, (17), 118-126
ISSN: 
  • 1045-2257
Related Link: 
  • http://www.ncbi.nlm.nih.gov/pubmed/8913729
  • https://www.researchgate.net/publication/14292835_Loss_of_heterozygosity_on_chromosome_arm_3p_in_nasopharyngeal_carcinoma
Accepted: 
  • Apr 13, 2015
URI: 
  • http://hdl.handle.net/1946/20758


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