is Íslenska en English

Grein

Háskóli Íslands > Heilbrigðisvísindasvið > Rit starfsmanna >

Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20805

Titill: 
  • Titill er á ensku High frequency of LOH at chromosome 18q in human breast cancer: Association with high S-phase fraction and low progesterone receptor content
Efnisorð: 
Útgáfa: 
  • Mars 1998
Útdráttur: 
  • Útdráttur er á ensku

    Human primary breast cancers were analysed for somatic loss of heterozygosity (LOH) at chromosome 18 with 15 polymorphic microsatellite markers. LOH was observed in 148 of the 228 cases analyzed (65%). Three smallest common deletion regions (SCDR) were detected on the long arm of chromosome 18. The marker D18S51 at the region 18q22 showed the highest LOH (42%). Tumors with and without LOH at 18q were tested for association with clinico-pathological features of the tumors, such as estrogen and progesterone receptor content, age at diagnosis, tumor size, node status, histological type, S-phase fraction DNA ploidy and LOH at other chromosomal regions. A significant association was found between LOH at 18q and high S-phase fraction (99.9% confidence interval) and low progesterone receptor. content (99%, confidence interval). Furthermore, an association was found between LOH at 18q and LOH at 1p, 7q, 9p, 13q and 17q. We conclude that there are three separate LOH target regions at chromosome 18q and that inactivation of one or. mole genes at these regions might be important for human breast carcinogenesis.

Styrktaraðili: 
  • Styrktaraðili er á ensku The Icelandic Research Council and the Icelandic Cancer Society
Birtist í: 
  • Anticancer Research, 1998, (18), 1031-1036
ISSN: 
  • 0250-7005
Tengd vefslóð: 
  • http://www.ncbi.nlm.nih.gov/pubmed/9615760
  • https://www.researchgate.net/publication/13668123_High_frequency_of_LOH_at_chromosome_18q_in_human_breast_cancer_association_with_high_S-phase_fraction_and_low_progesterone_receptor_content
Samþykkt: 
  • 17.4.2015
URI: 
  • http://hdl.handle.net/1946/20805


Skrár
Skráarnafn Stærð AðgangurLýsingSkráartegund 
ChenH1998AnticancerRes18q.pdf3.62 MBOpinnHeildartextiPDFSkoða/Opna