is Íslenska en English

Grein

Háskóli Íslands > Heilbrigðisvísindasvið > Rit starfsmanna >

Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/20808

Titill: 
  • Titill er á ensku Mapping loss of heterozygosity at chromosome 13q: Loss at 13q12-q13 is associated with breast tumour progression and poor prognosis
Efnisorð: 
Útgáfa: 
  • Desember 1998
Útdráttur: 
  • Útdráttur er á ensku

    Several chromosome regions exhibit loss of heterozygosity (LOH) in human breast carcinoma and are thought to harbour tumour suppressor genes (TSG). At chromosome 13q, two TSGs have been identified, RB1 at 13q14 and BRCA2 at 13q12-q13. In this study, 139 sporadic breast tumours were analysed with 18 polymorphic microsatellite markers for detailed mapping of LOH at chromosome 13q and evaluation of an association with known progression factors. LOH with at least one marker was observed in 71 (51%) of the tumours analysed. The deletion mapping indicated three LOH target regions, 13q12-q13, 13q14 and 13q31-q34. LOH at chromosome 13q12-q13 was associated with low progesterone receptor content, a high S phase fraction and aneuploidy. Multivariate analysis adjusting for lymph node involvement and S phase fraction showed that patients with tumours exhibiting LOH at 13q12-q13 have a 3-4-fold increased risk of recurrence and death compared with other patients. Our results suggest there are at least three separate LOH target regions at chromosome 13q and inactivation of one or more genes at chromosome 13q12-q13 results in poor prognosis for breast cancer patients.

Birtist í: 
  • European Journal of Cancer, 1998, (34), 2076-2081
ISSN: 
  • 0959-8049
Tengd vefslóð: 
  • http://www.sciencedirect.com/science/article/pii/S095980499800241X#
  • http://www.ncbi.nlm.nih.gov/pubmed/10070314
  • https://www.researchgate.net/publication/13221152_Mapping_loss_of_heterozygosity_at_chromosome_13q_loss_at_13q12-q13_is_associated_with_breast_tumour_progression_and_poor_prognosis
Samþykkt: 
  • 17.4.2015
URI: 
  • http://hdl.handle.net/1946/20808


Skrár
Skráarnafn Stærð AðgangurLýsingSkráartegund 
Eiriksdottir1998EJC13q.pdf161.57 kBOpinnHeildartextiPDFSkoða/Opna