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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/21943

Titill: 
  • Titill er á ensku Duplicated sequence motif in the long terminal repeat of maedi-visna virus extends cell tropism and is associated with neurovirulence
Útgáfa: 
  • Apríl 2007
Útdráttur: 
  • Útdráttur er á ensku

    Maedi-visna virus (MW) is a lentivirus of sheep causing chronic inflammatory disease of the lungs (maedi) and the nervous system (visna). We have previously shown that a duplicated sequence in the long terminal repeat (LTR) of MVV is a determinant of cell tropism. Here, we demonstrate that deletion of a CAAAT sequence from either one of the repeats resulted in poor virus growth in sheep choroid plexus cells. A duplication in the LTR encompassing the CAAAT sequence was found in four neurological field cases that were sequenced, but no duplication was present in the LTRs from seven maedi cases; one maedi isolate was mixed. These results indicate that the duplication in the LTR is associated with neurovirulence.

Birtist í: 
  • Journal of Virology, 2007, 81, 4052-4057
ISSN: 
  • 0022-538X
Tengd vefslóð: 
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866131/pdf/2319-06.pdf
  • http://jvi.asm.org/content/81/8/4052.full.pdf+html
  • http://www.ncbi.nlm.nih.gov/pubmed/17287273
  • https://www.researchgate.net/publication/6518057_Duplicated_sequence_motif_in_the_long_terminal_repeat_of_maedi-visna_virus_extends_cell_tropism_and_is_associated_with_neurovirulence
Samþykkt: 
  • 9.6.2015
URI: 
  • http://hdl.handle.net/1946/21943


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