is Íslenska en English

Grein

Háskóli Íslands > Heilbrigðisvísindasvið > Rit starfsmanna >

Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/22015

Titill: 
  • Titill er á ensku The MLH1-93 promoter variant influences gene expression
Útgáfa: 
  • Febrúar 2010
Útdráttur: 
  • Útdráttur er á ensku

    The −93 SNP of MLH1 gene is associated with MLH1 gene methylation in endometrial and colorectal cancers. We undertook luciferase reporter assay and electrophoretic mobility shift assay (EMSA) to test whether the −93 SNP affects the MLH1 gene expression. The luciferase activity for −93A plasmid is significantly lower than −93G plasmid. In EMSA experiments, the −93A and −93G probes have different binding affinity to nuclear proteins of JEG3 cells. Our data indicate that −93 SNP affects MLH1 gene expression by altering protein binding to the promoter of MLH1 gene.

Birtist í: 
  • Cancer Epidemiology 34 (2010), 93–95
ISSN: 
  • 1877-7821
Tengd vefslóð: 
  • http://ac.els-cdn.com/S187778210900188X/1-s2.0-S187778210900188X-main.pdf?_tid=3304005e-0f79-11e5-8b86-00000aab0f27&acdnat=1433945072_e1fbc5b8e0c4f133e47c22271c381fd7
  • http://www.sciencedirect.com/science/article/pii/S187778210900188X#
  • http://search.proquest.com/docview/1032597762/fulltextPDF/4B7D85926B7E4A14PQ/1?accountid=135775
  • http://www.ncbi.nlm.nih.gov/pubmed/20060799
  • https://www.researchgate.net/publication/40898548_The_MLH1-93_promoter_variant_influences_gene_expression
Samþykkt: 
  • 11.6.2015
URI: 
  • http://hdl.handle.net/1946/22015


Skrár
Skráarnafn Stærð AðgangurLýsingSkráartegund 
Mei2010CANEP.pdf149.75 kBOpinnHeildartextiPDFSkoða/Opna