Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/26385
Bariatric surgery is considered the most effective treatment for severe obesity, leading to weight loss with mean reductions of about 60% of excess weight or 14 kg/m2 BMI units, marked improvements in associated comorbidities such as hypertension, diabetes, obstructive sleep apnea, in addition to a decrease in mortality and large reductions in health-care costs.
The purpose of this study was to assess if physical activity could impact weight loss and BMD loss in subjects undergoing bariatric surgery, based on a 2-year short-term cohort study. Secondary aims were to assess long term weight loss and changes in BMD. Subjects were men and women, who underwent obesity treatment and gastric bypass surgery at Reykjalundur during 2010-2012, a total of 70 participants (aged 24-65 years old), 11 men and 59 women. Height, weight, bone mineral density and physical activity were measured.
After correcting for age and gender, a significant average weight loss from baseline to 12 months follow up for women 35,31 kg and men 41.43 kg (p<0.01). However, at 24 months follow up, men had gained on average 2.62 kg in comparison with the 12 months follow up (p<0.05) but women kept losing weight. There was significantly difference (p<0.01) from baseline to 12 months follow up, in BMD loss at wards triangle, trochanter, total hip and total spine for men but not at femoral neck but at all measurement sites for women (p<0.01 for all). At 24 months follow up, BMD was significantly lower than at baseline and at 12 months follow up at all measurement sites both for men and women (p<0.01). No significant correlations were found between weight loss and changes in BMD at any measurement site for men. A weak-to-moderate significant correlation were found between weight loss and changes in BMD between baseline and 12 months follow up for women in femoral neck, wards triangle, trochanter and total hip (p<0.001). Change in weight between baseline and 24 months was also weakly-to-moderately and significantly correlated with BMD changes in femoral neck, trochanter and total hip (p<0.001). No significant correlations were found between change in weight between 12 and 24 months and change in BMD during the same period. The differences in weight and BMD changes did not differ significantly across the categories of physical activity.
In conclusion, long term weight loss correlated with BMD loss following bariatric surgery, but the role of physical activity in these processes remains largely unknown. Many questions have risen, in particular related to the recommended intensities of physical activity. Physical activity did not correlate with weight loss or BMD at any point after the surgeries, therefore further research is required to find out what type and intensity of physical activity will be most effective in reducing loss of BMD and enhancing weight loss after bariatric surgery.