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Vinsamlegast notið þetta auðkenni þegar þið vitnið til verksins eða tengið í það: http://hdl.handle.net/1946/26429

Titill: 
  • Titill er á ensku Local Application of Metronidazole as an Adjunct to Surgical Debridement of Molar Furcation Sites
  • Titill er á ensku Staðbundin notkun metronidazole við tannhaldsskurðmeðferð á jöxlum með millirótabólgu
Námsstig: 
  • Meistara
Útdráttur: 
  • Útdráttur er á ensku

    Materials and methods
    Twenty patients referred to the Clinic of Periodontics at the Dental School, Gothenburg University for treatment of periodontitis were included in the study. To be included they had to have one pair of contralateral molars with a similar furcation involvement, class II in one furcation. As well the teeth had to be vital or properly endodontically treated and the patients had to be in good general health.
    All the participants were given cause related therapy; hygienic phase with oral hygiene instructions and their dentition scaled and root planed under local anaesthesia at the beginning of treatment.
    One month later baseline measurements were performed on the selected teeth. Plaque index (PlI) was measured at three sites, gingivitis index (GI) was measured at three sites, pocket probing depth (PPD) was measured at four sites, probing attachment level (PAL) was measured at four sites, horizontal attachment level (HAL) was measured at the furcations, bleeding on probing (BoP) was measured at four sites and finally bleeding on horizontal probing (HBoP) at the furcation. Periodontal flap surgery (modified Widman flap) was performed at all the sites involved in the study and metronidazole gel (Elyzol® Dental Gel, 25 % metronidazole) was applied under the flap before closure at one of the teeth for each subject. Which tooth received the antibiotic, test tooth (T) and which not, control tooth (C) was selected at random by tossing a coin.
    Sutures were removed one week later and followed by a repeated application of the metronidazole gel on the wound surface at the test sites. All patients were instructed to rinse with a 0.2 % chlorhexidine mouthrinse twice a day for four weeks following surgery.
    At four weeks the PlI and GI measurements were repeated.
    At six months all the clinical measurements made at baseline were repeated.
    Neither the examiner nor the patients were aware of which tooth was test and which was control (a double blind design).
    Results
    Initially 20 participants with equally many pairs of furcation involved molars took part in the study. Five dropped out or were excluded during the course of the study for various reasons, rendering results from 15 patients, 30 teeth.
    Statistical analysis in this study uses p < 0.05.
    Baseline plaque index (PlI) showed that 91 % T and 83 % C sites were plaque free. At four weeks the corresponding values were 74 % T and 74 % C. At six months final examination 80 % T and 73 % C were plaque free. No statistical difference was seen between T and C. Analyzing the data for PlI in the furcation only, equally did not reveal any difference.
    Baseline gingival index (GI) showed that 96 % T and 87 % C sites were free from gingivitis after the hygienic phase. At 4 weeks the corresponding values were 85 % T and 83 % C. At six months final examination 89 % T and 85 % C were gingivitis free. No statistical difference was found between T and C. Analyzing the data for GI in the furcation only, equally did not reveal any statistically significant difference.
    Overall mean pocket probing depth (PPD) was at baseline 3.8 mm for T and 4.2 mm for C, which is statistically different. At the six month final examination the mean PPD was T 3.2 mm and C 3.4 mm but this difference was not statistically significant. Looking at the same measurements for the furcations alone, they were at baseline T 4.7 mm and C 4.9 mm but at six month final examination T 3.8 mm and C 4.1 mm. No statistically significant differences were observed.
    Overall mean probing attachment level measurements (PAL) were reported in a similar way. At baseline they were 5.2 mm for T and 5.5 mm for C which is not statistically different. At the six month final examination the means for PAL were T 4.3 mm and C 5.2 mm and this difference reached statistical significance. Looking at the same measurements for the furcations only, they were at baseline T 6.0 mm and C 6.0 mm but at 6 month final examination T 5.0 mm and C 5.6 mm. No statistical difference was observed.
    Horizontal probing attachment level (HAL) was at baseline T 5.2 mm and C 5.5 mm but at the six months final examination T 3.3 mm and C 3.1 mm. The difference was not significant statistically.
    Baseline bleeding on probing (BoP) was T 62 % and C 75 %, this difference showing statistically significant difference. At six months this difference had disappeared; T 33 % and C 28 %. No statistical difference was observed looking at the same measurements for solely the furcation area; T 86 % and C 93 % at baseline and T 46 % and C 36 % at six months.
    Finally, mean baseline horizontal bleeding on probing (HBoP) measured T 100 % and C 100 %, at six month final examination these values were down to T 60 % and C 53 %. No statistical difference between groups T and C was observed.

Samþykkt: 
  • 30.11.2016
URI: 
  • http://hdl.handle.net/1946/26429


Skrár
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Local Application of Metronidazole as an Adjunct to Surgical Debridement of Molar Furcation Sites .pdf528.25 kBOpinnHeildartextiPDFSkoða/Opna
Ingólfur E.pdf494.74 kBLokaðurPDF